Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.
Co-op Assignment Overview
Prime Medicine is seeking a Co-Op for the Spring 2025 semester with strong knowledge in chemistry/biochemistry to join our guide RNA chemistry team. The qualified candidate will be involved in the synthesis, purification, and analysis of oligonucleotides. In this position, you will gain comprehensive knowledge and hands-on experience in solid-phase synthesis, purifications, desalting, lyophilization, and analysis of long oligonucleotides for supporting prime editing programs.
Primary Responsibilities:
- Support solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers.
- Assist in HPLC purification and UPLC and LCMS analysis of research scale long oligonucleotides.
- Preparing buffers and solutions for guide RNA purification and analysis.
- Track and manage chemical, reagent, and consumables inventory and ordering.
- Assist with maintenance and troubleshooting lab equipment such as synthesizers, speedvacs, lyophilizers, and HPLC instrumentation.
- Maintain a well-documented electronic laboratory notebook (ELN). Track progress, analyze, interpret, and present data within the team and cross-functional teams.
- Conducting lab work safely and efficiently, ensuring a safe working environment for colleagues.
Qualifications:
- B.S. candidate in Chemistry/Biochemistry or related subjects.
- Prior experience working in a chemistry or biochemistry laboratory.
- A high degree of flexibility and self-motivation in a fast-paced work environment with excellent organizational skills and the ability to prioritize appropriately and meet timelines.
- Excellent troubleshooting and communication skills.
- Ability to work independently and within a team.
Preferred Qualifications
- Chemistry or Biochemistry major with basic knowledge of organic chemistry.
- Basic knowledge of common computer programs (Excel, Work, and PowerPoint).
- Independently motivated, detail-oriented, and excellent problem-solving abilities.
- Prior experience in nucleic acid chemistry is a plus.
- Hands-on experience with HPLC, UPLC, and LCMS is a plus.
What We Offer:
- A cutting-edge team open to mentorship and networking.
- Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
- Participation in regular seminars with industry experts.
- Full participation in employee activities including learning and development offerings, social activities, etc.
NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.