Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Fall 2023 semester with interest in nucleic acid R&D to join the process chemistry team. The candidate will be involved in day-to-day routine laboratory activities for supporting in-process analytics including UV measurement, UPLC and LC-MS analysis, integration for UPLC chromatograms of various stages in-process guide RNA samples. The candidate will learn a variety of in-process analytics quickly, will generate data and document them in the Prime’s project specific folder, and will share results at scientific team meetings. 

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being. 

Primary Responsibilities: 

  • Supports in-process analytics for Prime’s long guide RNA (ribonucleic acid) platform development using various laboratory techniques such as UPLC, LC-MC, Nano drop, Osmometer, Karl Fisher etc. 
  • Routine UPLC analysis of RNA oligonucleotides (crude sample, fractions, pool, pre & post-TFF samples) for multiple guide RNA. 
  • Maintain a log sheet for all in-process sample analysis 
  • Maintain the lab instruments such as UPLC, Nano drop, LC-MS etc. in good operational condition after use 
  • Documents data in the Prime’s project specific folder, write a project summary report in brief and share results at scientific team meetings. 


  • Must be enrolled in the undergraduate/advanced degree program at the time of Co-op program 
  • Excellent written and oral communication skills, good organization skills, the ability to multi-tasks, and work as a team player and independently. 
  • A passion for learning and contributing to multiple facets of a program
  • Have completed General Chemistry, Analytical Chemistry lecture/lab course 

Preferred Qualifications: 

  • Prior relevant internship/Co-op experience. 
  • Familiarity working in chemistry laboratory, and experience with instrumentation such as UPLC, LC-MS, Nano drop is a plus.
  • Familiarity about drug substance characterization is a plus 

What We Offer: 

  • A cutting-edge scientific team open to mentorship and networking 
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc. 
  • Participation in regular scientific seminars with industry experts 
  • Full participation in employee activities including learning and development offerings, social activities, etc. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

apply now_