Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Fall 2023 semester with experience in cell biology, chemical engineering or bioengineering to join the Cell PD team. The candidate will be involved in developing and characterizing a cell therapy manufacturing process involving prime editing of primary human cells for the treatment of hematological indications. The candidate will work in a highly collaborative team across Technical Operations and R&D in a fast-paced, exciting lab-based work environment. In this role, you will learn about the principles of bioprocessing, ex vivo gene editing and hematopoietic stem cell biology. 

Primary Responsibilities: 

  • Primary and immortalized cell culture and passaging 
  • Kitting, verification and assistance during cell therapy process development runs with a small team 
  • Assist with characterization (i.e., cell counting, flow cytometry, biochemical assays) of samples generated during scaled-up cell process runs 
  • Small-scale process development experiments (e.g., cell enrichments)
  • Contribute to trouble-shooting of process unit operations
  • Data compilation, analysis and interpretation, including presentations to the team 


  • B.S. candidate in Biology area or Bio/Chemical Engineering 
  • Hands-on experience with aseptic techniques (cell/tissue culture)
  • Experience with data analysis software (Excel, Prism, MATLAB)
  • Ability to accurately record experiments and observations
  • Team player who can also work independently
  • Effective verbal and written communication
  • Attention to detail 

Preferred Qualifications: 

  • Experience with cell-based and/or molecular biology assays 
  • Familiarity with bioprocessing principles 
  • Previous co-op experience in biotechnology industry
  • Problem-solver who enjoys troubleshooting
  • Highly motivated with desire to learn new techniques 

What We Offer: 

  • A cutting-edge scientific team open to mentorship and networking 
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc. 
  • Participation in regular scientific seminars with industry experts 
  • Full participation in employee activities including learning and development offerings, social activities, etc. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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