Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Fall 2023 semester with experience in cell and molecular biology to join the Liver team. The qualified candidate will be part of a highly collaborative fast paced project team working to validate the effectiveness of promising Prime Editors in primary cells. In addition, the candidate will be involved in establishing cellular and molecular assays that demonstrate positive phenotypic changes due to Prime Editing. In this position, you will learn and perfect cell and molecular biology skills and develop a deep understanding of gene editors and how they are delivered to liver cells 

Primary Responsibilities: 

  • Maintain primary cell culture and perform different types of transfections in cells 
  • Aseptic primary cell culture techniques  
  • Assist with validation of Prime Editors to target specific disease-causing mutations 
  • Processing gDNA for sequencing analysis (extraction, PCR, MiSeq preprocessing)
  • Extract DNA/RNA/protein from the cells for downstream analysis 
  • Document, present, and communicate experimental data and conclusions in electronic notebook. 


  • Completing BS or MS in Molecular Biology/Cell Biology/Biomedical Science
  • Mammalian cell culture experience and aseptic techniques
  • Experience in experimental design, optimization, and analysis 
  • Ability to work independently and within a team and cross functional teams
  • Excellent troubleshooting and communication skills 

Preferred Qualifications: 

  • Hands-on experience with cell culture is preferred 
  • Experience with basic molecular biology assays (DNA extraction, PCR etc) 
  • Familiarity with excel and PowerPoint for data analysis 
  • Independently motivated, detail-oriented, and excellent problem-solving abilities 

What We Offer: 

  • A cutting-edge scientific team open to mentorship and networking 
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc. 
  • Participation in regular scientific seminars with industry experts 
  • Full participation in employee activities including learning and development offerings, social activities, etc. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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