Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Fall 2023 cycle with experience in Biology to join the Hematology/Immunology team. The qualified candidate will work with a highly collaborative fast paced project team to build assays, test delivery methods, and validate promising Prime Editors for hematological, immunological and cell therapy indications. In this position, you will learn and perfect cell and molecular biology skills and develop a deep understanding of gene editing and hematopoietic stem cell and immune cell biology.  

Primary Responsibilities: 

  • Grow and maintain primary human cells and cell lines using aseptic techniques 
  • Set up assays to evaluate different methods of delivery of prime editing reagents 
  • Assist with clonal analysis of prime edited cells  
  • Process gDNA for sequencing analysis (extraction, PCR, MiSeq preprocessing)
  • Prepare samples and running flow cytometry assays
  • In vivo sample harvesting and processing for downstream analysis
  • Data analysis, interpretation, and presentations within the team 


  • B.S. candidate in Cell & Molecular Biology or related major
  • Basic knowledge of molecular biology, cell biology and biochemistry.  
  • Excellent troubleshooting and communication skills 
  • Ability to work independently and within a team 

Preferred Qualifications: 

  • Hands-on experience with cell culture is preferred
  • Experience with basic molecular biology assays (DNA extraction, PCR etc)
  • Familiarity with excel and PowerPoint for data analysis
  • Independently motivated, detail-oriented, and excellent problem-solving abilities 

What We Offer: 

  • A cutting-edge scientific team open to mentorship and networking 
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc. 
  • Participation in regular scientific seminars with industry experts 
  • Full participation in employee activities including learning and development offerings, social activities, etc. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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