Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview:

We are currently seeking a motivated and accomplished Engineer I/Engineer II to join the Automated Assays and Operations team in Prime’s growing Technical Development and Operations Organization. This individual will focus on developing and automating plate-based analytical assays, including ELISA and cell-based assays, for the characterization, stability, and release testing of critical reagents, drug substance (DS), and drug product (DP). This role is hands-on and a successful candidate will be involved in automated system design, integration, programming, implementation, and maintenance as well as assay development and qualification. This role interfaces will all parts of the company from early discovery to QC testing, and therefore the ideal candidate will work well in a matrixed environment.

This is a hands-on role where the successful candidate will be involved in day-to-day activities in assay development supporting programs in development and discovery stage. The ideal candidate will excel in a matrixed environment, as this role will interface with the process development, pharmacology, formulation, biology, and quality teams to advance Prime’s prime editing pipeline. Our ideal candidate is a creative problem solver with the energy to drive an ambitious assay development, automation and operations agenda, which support Prime’s development programs’ goals.

Key Responsibilities:

  • Design, integrate, and program automation systems
  • Design, develop, and automate plate-based (ELISA, Cell-based, mix and read) assays
  • Run and qualify assays
  • Integrate workflows with ELN and LIMS to support scalability and flexibility.
  • Identify bottlenecks impeding the team, and proactively implement solutions.
  • Work with scientists to understand current workflows, assay design, and automation needs
  • Identify metrics to be collected from workflows, and creation of system for metrics collection, visualization, and reporting in order to identify improvement areas
  • Continually look for new or improved technologies to evaluate for increasing capacity or optimization
  • Work with instrument vendors and external contractors to evaluate, design, and implement new solutions.


  • BS + 5 years/MS + 3 years in Biology or Engineering disciplines.
  • Experience in plate-based assay development, with emphasis on mix-and-read, ELISA, and cell-based assays
  • Experience in lab automation, including liquid handlers (Tecan, Hamilton, Dynamic Devices, etc), scheduling software (Cellario, Genera, Green Button Go), and robotic arms (Precise, KX-2)
  • Programming proficiency (.NET, C++, C#, python, java)
  • Strong collaborator with cross-functional teams and external partners
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
  • Highly self-motivated, driven, can-do, make it happen attitude with ability to own and drive projects
  • Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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