Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview:

We are seeking a talented and motivated Senior Associate Scientist I who will be a key member of the Cell Therapy process development team.  She/he will collaborate with CMC leadership, scientists across various functional groups at Prime Medicine, as well as external partners to contribute to the development, optimization, and tech transfer of a manufacturing process for prime editing ex vivo cells. This is a hands-on role where the successful candidate will be directly involved in several process development and tech transfer activities. This is an exciting opportunity to work at the intersection of cell biology, cell therapy, bioengineering, and clinical manufacturing to advance genetic medicine and help patients. The ideal candidate will excel as a member of a cross-functional team working closely with colleagues in Hematology research, technical development, external manufacturing, and Quality to advance Prime’s pipeline.

Primary Responsibilities:

  • Execute process development activities using biological and engineering principles to develop and improve various unit operation to support ex vivo gene editing programs
  • Work closely with team members to implement process development findings and analytical insights into manufacturing processes
  • Contribute to technical reports, standard operating procedures, and draft batch records
  • Serve as a Subject Matter Expert (SME) during process development and technology transfer to CDMO, and partner with CDMO to support cGMP manufacturing of prime edited drug products
  • Keep meticulous experimental records in an electronic lab notebook
  • Support new technology evaluations with emphasis on cell yields and viability, prime editing efficiency, process robustness, and control
  • Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports including protocols, and technical reports

Basic Qualifications:

  • A BS or MS in biology, bioengineering, biological science, or related life science discipline with ideally 3+/1+ years of relevant industrial experience in cell and gene therapy
  • Experience in cell therapy process development
  • Prior hands-on experience with equipment and unit operations typically used in process development and manufacturing of cell therapy products is required
  • Experience collaborating with CDMOs in an GMP environment including technology transfer and technical troubleshooting
  • Working knowledge of statistical software (e.g., JMP) is preferred
  • Prior experience developing and writing standard operating procedures and draft batch record is a plus
  • Strong written and verbal communication skills
  • Able to creatively manage time and elevate relevant issues to other team members and team lead
  • Able to work both independently and collaboratively in a fast-paced, dynamic, entrepreneurial, and team-based setting.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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