Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview:

Prime Medicine is seeking a co-op for the Spring 2023 semester with experience in biochemistry and molecular biology to join the Prime Editing Platform team. The candidate will be involved in characterizing and engineering novel RNA-guided endonucleases for use as Prime Editing components.

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

  • Design, develop, optimize, and execute in-vitro assays for RNA guided nucleases such as activity screening, enzyme activity kinetics and enzyme binding kinetics.
  • Perform all aspects of molecular biology, cloning and nucleic acid purification (e.g., primer design, PCR, vector construction, agarose gel electrophoresis, plasmid prep)
  • Compile experimental summaries and present to members of the Prime Editing Platform team
  • Keep meticulous experimental records and document in electronic lab notebooks (ELN)
  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality

Qualifications:

  • Finishing a BS or MS in Molecular Biology/Engineering/Biochemistry
  • Experience in molecular biology and molecular cloning (primer design, PCR, plasmid assembly, e coli transformation and cultivation, DNA purification)
  • Experience in enzyme characterization (Western blot and SDS-PAGE)
  • Experience with manipulation and characterization of DNA/RNA (native and denaturing gel electrophoresis and NGS and Sanger sequencing)

Preferred Qualifications:

  • Experience in mammalian cell tissue culture (e.g., HEK293T cells)
  • Familiarity with DNA analysis software (e.g., Snapgene, Geneious, Vector NT, Primer 3) and data analysis software (e.g., Graphpad Prism, Flowjo)
  • Demonstrated maturity and scientific contributions within a complex matrixed organization

What We Offer: 

  • A cutting-edge scientific team dedicated to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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