Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview:

Prime Medicine is seeking a co-op for the Spring 2023 semester with experience in cell biology and genomics to join the off-target team. In addition to the intended genome edit, all genomic editing approaches can potentially introduce unintended edits at other genomic locations. These off-target events may produce undesirable outcomes when gene editing is applied clinically. The off-target group at Prime Medicine develops approaches to identify these events, evaluate potential impact, and minimize their occurrence. The candidate will be involved in developing approaches to identify off-target events at the single cell level using modern genomic approaches.

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to improving human health and well-being.

Primary Responsibilities:

  • Carrying out genome editing experiments under the direction of the mentor
  • Performing single cell assays including DNA- and RNA-seq on gene edited cells
  • Analysis and presentation of experimental results


  • Experience in basic molecular biology (eg. DNA and RNA purification, PCR)
  • Exposure to or experience with cell biology and cell culture
  • Expertise in data analysis (eg. Knowledge of basic statistical tests and approaches

Preferred Qualifications:

  • Knowledge and/or experience in gene editing
  • Practical experience with Next-Generation Sequencing

What We Offer:

  • A cutting-edge scientific team dedicated to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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