Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview

We’re looking for an outstanding program leader with significant experience advancing early stages programs to IND approval.   This leader will help establish our program management methodology and lead program management in our early research teams, both leading programs as well as helping to build out Prime Medicine’s program management team and function.  For the right candidate, this could also include heading our Program Management function. This role reports to the Senior Vice President, Strategy and Corporate Operations and will work with our Cambridge, MA-based teams.



As a Program Manager:

  • Develop and guide program strategy, set program goals and facilitate team decision making for the program, working in partnership with research team leadership
  • Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, decision making support, portfolio management activities and internal reporting
  • Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
  • Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
  • Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans
  • Facilitate strong cross-functional communication by building strong working relationships across the organization
  • Develop materials and present program updates/progress at internal company meetings

Building out the Program Management function:

  • Develop the Prime Medicine program management function and establish Prime methodology and best practices
  • Responsible for the creation, management, and communication of Prime’s overall programs plan
  • Facilitate cross-functional communication, including input to Leadership Team on program progress
  • Facilitate strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through appropriate governance forums
  • Build high standards and high performing teams to advance our science
  • Drive strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises
  • Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable


  • Direct experience in program management/program leadership for discovery through early clinical development programs; 10+ years in industry with 5+ years managing programs
  • Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; cell therapy and gene editing experience highly desired
  • Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict
  • Proficient in prioritizing and driving complex programs to milestone completion
  • Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management
  • Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

apply now_