Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview

We are currently seeking a talented and motivated Scientist/Senior Scientist with strong expertise in cell-based analytics to join the analytical development team in Prime’s growing Technical Development and Operations group. Reporting to the VP & Head of Analytical, Formulation, and Early Phase QC Testing, this individual will develop and apply cell-based assays for the characterization of critical reagents, and develop functional potency assays for drug substance and drug product release and stability testing at Prime Medicine. This is a hands-on role where the successful candidate will be involved in day-to-day activities in genomic, proteomic, and functional assay development. The ideal candidate will be highly independent and will excel in a matrixed environment, as this role will interface with the process development, pharmacology, formulation, biology, and quality teams to advance Prime’s prime editing pipeline.    

 Key Responsibilities:

  • Develop, optimize, and apply cell-based potency assays for the characterization and release testing of cell and gene therapy products including in vivo and ex vivo delivered drugs
  • Independently plan and execute experiments, perform data analysis and interpretation
  • Generate, evaluate, and maintain critical data, including performing statistical analysis
  • Provide oversight of external CTL (contract testing lab)/CDMO (contract development and manufacturing organizations) and perform internal early-stage assay qualification, validation and sample testing
  • Proactively evaluate new technologies, stay up-to-date with current literature, and implement new features and functionalities into Prime’s cell analytics platform
  • Author, review, and approve protocols, SOPs, technical documents, and analytical sections of regulatory submissions
  • Maintain thorough electronic lab notebooks and documentation records, and present findings to multi-disciplinary teams in various oral and written formats

Qualifications

  • MS/PhD in cell biology, immunology, molecular biology, or related discipline with 5+ (MS) or 2+ (PhD) years of relevant experience
  • Experience in development of cell-based potency assays, including developing potency assays cell and gene therapy programs
  • Proficiency in cell culture, transfection, PCR, western blot, MSD, ELISA, reporter assays, and fluorescence imaging
  • Experience in cellular mechanism of action studies
  • Experience with qualifying and validating assays and understanding of ICH/FDA guidelines is strongly desirable
  • Experience with flow cytometry is a plus
  • Experience in management of external CMO/CDMOs is a plus
  • Familiarity with liquid handling instruments and automation platforms (e.g. Biomek, Hamilton) is a plus
  • Highly self-motivated and driven with a can-do, make it happen attitude and ability to own and drive projects
  • Strong collaborator with cross-functional teams and external partners
  • Ability to adapt quickly in a fast-paced environment with changing priorities
  • Highly organized and detail-oriented

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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