Principal Scientist/Associate Director/Director, Hematology/Immunology

Research

Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Position Overview

We are currently seeking a motivated self-starter and experienced scientist with expertise in hematopoietic stem cell therapy, cellular immunotherapy (i.e., engineered T and NK cell therapies). The candidate will join and contribute to a multidisciplinary program team focused on developing novel engineered prime edited cell therapies focused on the treatment of inherited genetic diseases, diseases affecting the immune system, and cancer. The candidate will apply her/his deep expertise to evaluate and optimize prime editing of human hematopoietic cells and characterize cell biology of edited cells (phenotype, function, engraftment, and differentiation) using in vitro and in vivo assays

Primary Responsibilities:

  • Lead research projects and collaborate with other team members to meet program goals.
  • Contribute to strategic planning on hematologic indication section for development of next generation prime editing therapeutics
  • Work with team to design, plan, and execute ex vivo and in vivo studies with human CD34+
  • Interpret results generated from flow cytometry, NGS, RNA-seq, and other complex data sets
  • Coordinate, collaborate, and work with various other groups in a matrixed environment, as well as external academic collaborations and CROs.
  • Manage and mentor scientists.
  • Present data and findings to internal and external scientific groups.

Qualifications:

  • PhD in a relevant field (e.g., Hematopoiesis, Immunology, Molecular or Cell Biology) with experience in gene editing and/or gene therapy applications at clinically relevant target sites in CD34+ cells and/or immune cells (T, NK cells)
  • 8+ years postdoc and/or biotech industry experience with demonstrated success leading projects.
  • Strong publication record demonstrating significant contributions to the fields of HSC biology, immunology, and hematopoietic cell therapy.
  • Experience in the isolation, culture and in vitro/in vivo characterization of human hematopoietic progenitors and/or lymphocytes
  • Experience in managing a research team and/or CROs in an industry setting a significant plus
  • Strong self-motivation and ability to pivot to new directions as data develops in multidisciplinary space
  • Deep knowledge of and experience in gene editing technologies (e.g., ZFN, TALEN, CRISPR, base editors)
  • Experience collaborating on cross-functional teams, willingness to roll-up-sleeves to get things done.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.