Company Overview

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.  A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.  

We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.  Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Fall 2023 semester with experience in molecular/cell biology-related wet-lab work to join the Neuromuscular team. The qualified candidate will work with a highly collaborative, fast-paced project team to validate Prime Editors hits using a suite of phenotypic assays in disease-relevant cell models for multiple neuromuscular disease indications. The candidate will receive regular mentorship weekly and will learn a variety of different lab-based techniques and computational skills. Furthermore, the co-op will learn about data analysis/interpretation and will present his/her/their work in team/function meetings. In this position, the candidate will develop a deep understanding of gene editing in neuromuscular diseases and the early drug discovery process. 

Primary Responsibilities: 

  • Support the neuromuscular team in the development of prime editing-based therapeutics 
  • Design and optimize PEgRNA sequences, and evaluate editing efficiency in cell models 
  • Validate PEgRNA hits in relevant cell models using various phenotypical assays 
  • In vivo sample processing for downstream analysis
  • Data analysis, interpretation, and presentations within the team 


  • B.S. candidate in Biology or related major 
  • Good understanding about genome editing 
  • Previous wet-lab (molecular/cell biology) experience 
  • Excellent troubleshooting and communication skills  

Preferred Qualifications: 

  • B.S. degree in biology or related field
  • Excel at some of listed lab techniques: immune-staining, PCR, qRT-PCR, western blot, nucleotide extraction, molecular cloning, fluorescence-activated cell sorting
  • Experience with maintaining cell lines, primary cells, or IPSCs
  • Experience with computational biology skills (Python, R) 

What We Offer: 

  • A cutting-edge scientific team open to mentorship and networking 
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc. 
  • Participation in regular scientific seminars with industry experts 
  • Full participation in employee activities including learning and development offerings, social activities, etc. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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